The regulation of INK4/ARF in cancer and aging

William Y Kim; Norman E Sharpless

doi:10.1016/j.cell.2006.10.003

The regulation of INK4/ARF in cancer and aging

Cell. 2006 Oct 20;127(2):265-75. doi: 10.1016/j.cell.2006.10.003.

Authors

William Y Kim¹, Norman E Sharpless

Affiliation

¹ Department of Medicine, The University of North Carolina School of Medicine, Chapel Hill, 27599, USA.

PMID: 17055429
DOI: 10.1016/j.cell.2006.10.003

Abstract

Loss of the INK4a/ARF/INK4b locus on chromosome 9p21 is among the most frequent cytogenetic events in human cancer. The products of the locus--p15(INK4b), p16(INK4a), and ARF--play widespread and independent roles in tumor suppression. Recent data also suggest that expression of p16(INK4a) induces an age-dependent decrease in the proliferative capacity of certain tissue-specific stem cells and unipotent progenitors. Here, we discuss the regulation and role of p16(INK4a), ARF, and p15(INK4b) in cancer and aging.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

ADP-Ribosylation Factors / genetics
ADP-Ribosylation Factors / metabolism*
Aging / metabolism*
Animals
Cell Transformation, Neoplastic / metabolism*
Cellular Senescence
Cyclin-Dependent Kinase Inhibitor Proteins / genetics
Cyclin-Dependent Kinase Inhibitor Proteins / metabolism*
Cyclin-Dependent Kinase Inhibitor p15 / metabolism
Cyclin-Dependent Kinase Inhibitor p16 / metabolism
Gene Expression Regulation, Neoplastic
Gene Silencing
Humans

Substances

Cyclin-Dependent Kinase Inhibitor Proteins
Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p16
ADP-Ribosylation Factors