Evolutionary history of the ABCB2 genomic region in teleosts

Dev Comp Immunol. 2007;31(5):483-98. doi: 10.1016/j.dci.2006.07.010. Epub 2006 Sep 20.

Abstract

Gene duplication, silencing and translocation have all been implicated in shaping the unique genomic architecture of the teleost MH regions. Previously, we demonstrated that trout possess five unlinked regions encoding MH genes. One of these regions harbors ABCB2 which in all other vertebrate classes is found in the MHC class II region. In this study, we sequenced a BAC contig for the trout ABCB2 region. Analysis of this region revealed the presence of genes homologous to those located in the human class II (ABCB2, BRD2, psiDAA), extended class II (RGL2, PHF1, SYGP1) and class III (PBX2, Notch-L) regions. The organization and syntenic relationships of this region were then compared to similar regions in humans, Tetraodon and zebrafish to learn more about the evolutionary history of this region. Our analysis indicates that this region was generated during the teleost-specific duplication event while also providing insight about potential MH paralogous regions in teleosts.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • ATP-Binding Cassette Transporters / genetics*
  • Amino Acid Sequence
  • Animals
  • Contig Mapping
  • Evolution, Molecular*
  • Fishes / genetics*
  • GTPase-Activating Proteins / genetics
  • Gene Duplication
  • Gene Expression Profiling
  • Gene Order
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics
  • Major Histocompatibility Complex / genetics*
  • Models, Genetic
  • Molecular Sequence Data
  • Oncorhynchus mykiss / genetics
  • Phylogeny
  • Protein-Serine-Threonine Kinases / genetics
  • Proto-Oncogene Proteins / genetics
  • Receptors, Notch / genetics
  • Sequence Homology, Amino Acid
  • Synteny
  • Transcription Factors / genetics
  • Zebrafish / genetics
  • rab GTP-Binding Proteins / genetics

Substances

  • ATP-Binding Cassette Transporters
  • GTPase-Activating Proteins
  • Intracellular Signaling Peptides and Proteins
  • Proto-Oncogene Proteins
  • Receptors, Notch
  • Transcription Factors
  • Protein-Serine-Threonine Kinases
  • rab GTP-Binding Proteins

Associated data

  • GENBANK/DQ246664