Stimulus responsive elastin biopolymers: Applications in medicine and biotechnology

Curr Opin Chem Biol. 2006 Dec;10(6):652-7. doi: 10.1016/j.cbpa.2006.10.010. Epub 2006 Oct 19.


Elastin-like polypeptides (ELPs) are artificial polypeptides, derived from Val-Pro-Gly-Xaa-Gly (VPGXG) pentapeptide repeats found in human tropoelastin, that reversibly coacervate above a critical temperature. Genetically encodable ELPs are monodisperse, stimuli responsive, and biocompatible, properties that make them attractive for drug delivery and tissue engineering. The potential of ELPs to self-assemble into nanostructures in response to environmental triggers is another interesting feature of these polypeptides that promises to lead to a host of new applications.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Biotechnology*
  • Elastin / chemistry*
  • Elastin / isolation & purification
  • Recombinant Fusion Proteins / chemistry
  • Recombinant Fusion Proteins / isolation & purification
  • Tissue Engineering


  • Recombinant Fusion Proteins
  • Elastin