Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 12 (11), 1294-300

Genomic Signatures to Guide the Use of Chemotherapeutics

Affiliations

Genomic Signatures to Guide the Use of Chemotherapeutics

Anil Potti et al. Nat Med.

Erratum in

  • Nat Med. 2007 Nov;13(11):1388
  • Nat Med. 2008 Aug;14(8):889

Retraction in

Abstract

Using in vitro drug sensitivity data coupled with Affymetrix microarray data, we developed gene expression signatures that predict sensitivity to individual chemotherapeutic drugs. Each signature was validated with response data from an independent set of cell line studies. We further show that many of these signatures can accurately predict clinical response in individuals treated with these drugs. Notably, signatures developed to predict response to individual agents, when combined, could also predict response to multidrug regimens. Finally, we integrated the chemotherapy response signatures with signatures of oncogenic pathway deregulation to identify new therapeutic strategies that make use of all available drugs. The development of gene expression profiles that can predict response to commonly used cytotoxic agents provides opportunities to better use these drugs, including using them in combination with existing targeted therapies.

Comment in

Similar articles

See all similar articles

Cited by 144 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback