Collecting and organizing systematic sets of protein data

Nat Rev Mol Cell Biol. 2006 Nov;7(11):803-12. doi: 10.1038/nrm2042.


Systems biology, particularly of mammalian cells, is data starved. However, technologies are now in place to obtain rich data, in a form suitable for model construction and validation, that describes the activities, states and locations of cell-signalling molecules. The key is to use several measurement technologies simultaneously and, recognizing each of their limits, to assemble a self-consistent compendium of systematic data.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cluster Analysis
  • Computational Biology / methods*
  • Computational Biology / statistics & numerical data
  • Databases, Protein*
  • Gene Expression Regulation*
  • Humans
  • Immunoassay
  • Models, Biological
  • Protein Processing, Post-Translational*