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Review
. 2006 Nov;7(11):833-46.
doi: 10.1038/nrm2039.

Protein Tyrosine Phosphatases: From Genes, to Function, to Disease

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Review

Protein Tyrosine Phosphatases: From Genes, to Function, to Disease

Nicholas K Tonks. Nat Rev Mol Cell Biol. .

Abstract

The protein tyrosine phosphatase (PTP) superfamily of enzymes functions in a coordinated manner with protein tyrosine kinases to control signalling pathways that underlie a broad spectrum of fundamental physiological processes. In this review, I describe recent breakthroughs in our understanding of the role of the PTPs in the regulation of signal transduction and the aetiology of human disease.

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