Protein tyrosine phosphatases: from genes, to function, to disease

Nat Rev Mol Cell Biol. 2006 Nov;7(11):833-46. doi: 10.1038/nrm2039.


The protein tyrosine phosphatase (PTP) superfamily of enzymes functions in a coordinated manner with protein tyrosine kinases to control signalling pathways that underlie a broad spectrum of fundamental physiological processes. In this review, I describe recent breakthroughs in our understanding of the role of the PTPs in the regulation of signal transduction and the aetiology of human disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Binding Sites
  • Gene Expression Regulation*
  • Humans
  • Ligands
  • Models, Biological
  • Neoplasms / enzymology*
  • Neoplasms / etiology
  • Oxidation-Reduction
  • Protein Tyrosine Phosphatases / classification
  • Protein Tyrosine Phosphatases / genetics*
  • Protein Tyrosine Phosphatases / physiology
  • Signal Transduction*
  • Structure-Activity Relationship
  • Tumor Suppressor Proteins / genetics
  • Tumor Suppressor Proteins / physiology*
  • Tyrosine / metabolism


  • Ligands
  • Tumor Suppressor Proteins
  • Tyrosine
  • Protein Tyrosine Phosphatases