Intraventricular infusion of HBGF-2 promotes cerebral angiogenesis in Wistar rat

Brain Res. 1990 Nov 26;534(1-2):283-6. doi: 10.1016/0006-8993(90)90140-7.


The angiogenic effects of chronic intraventricular infusion of basic fibroblastic growth factor (HBGF-2) were assessed in the Wistar rat cerebral cortex. HBGF-2 increased both capillary density and area of perfused vasculature without altering capillary diameters in periventricular cortex adjacent to the site of infusion. Although it has been demonstrated that growth factors can cause brain endothelial proliferation in vitro, this is the first report of in vivo cerebral angiogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blood Pressure / drug effects
  • Capillaries / pathology
  • Cerebral Ventricles / blood supply*
  • Cerebral Ventricles / drug effects
  • Cerebral Ventricles / pathology
  • Fibroblast Growth Factor 2 / administration & dosage
  • Fibroblast Growth Factor 2 / toxicity*
  • Injections, Intraventricular
  • Neovascularization, Pathologic / pathology*
  • Rats
  • Rats, Inbred Strains
  • Reference Values


  • Fibroblast Growth Factor 2