Lipophilicity relationships in inhibitors of CYP2C9 and CYP2C19 enzymes

J Enzyme Inhib Med Chem. 2006 Aug;21(4):385-9. doi: 10.1080/14756360600703313.

Abstract

Quantitative structure-activity relationships (QSARs) within a series of cytochrome P450 2C9 (CYP2C9) and cytochrome P450 2C19 (CYP2C19) inhibitors are reported. In particular, it is noted that compound lipophilicity, in the form of log P values (where P is the octanol/water partition coefficient), is an important factor in explaining the variation in inhibitory potency within these series of compounds, many of which also act as substrates for the respective enzymes. In addition, there is a role for hydrogen bonding and pi-pi stacking interactions within the P450 active site which represent secondary factors in the binding processes of these compounds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents / pharmacology
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Aryl Hydrocarbon Hydroxylases / chemistry*
  • Binding Sites
  • Crystallography, X-Ray
  • Cytochrome P-450 CYP2C19
  • Cytochrome P-450 CYP2C9
  • Drug Design
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Hydrogen Bonding
  • Hydrogen-Ion Concentration
  • Kinetics
  • Mixed Function Oxygenases / chemistry*
  • Octanols / chemistry
  • Protein Structure, Secondary
  • Quantitative Structure-Activity Relationship
  • Water / chemistry

Substances

  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Enzyme Inhibitors
  • Octanols
  • Water
  • Mixed Function Oxygenases
  • CYP2C9 protein, human
  • Cytochrome P-450 CYP2C9
  • Aryl Hydrocarbon Hydroxylases
  • CYP2C19 protein, human
  • Cytochrome P-450 CYP2C19