The drug development crisis: efficiency and safety

Annu Rev Med. 2007;58:1-16. doi: 10.1146/


Despite advancements in genetics, chemistry, and protein engineering, recent years have seen fewer approvals of new drugs, increases in development costs, and high-profile drug withdrawals. This article focuses on technologic methods for improving drug development efficiency. These technologies include high-content cell screening, expression profiling, mass spectroscopy, mouse models of disease, and a post-launch screening program that enables investigations of adverse drug effects. Implementation of these new technologies promises to improve performance in drug development and safety.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomedical Technology / methods*
  • Clinical Trials as Topic*
  • Disease Models, Animal
  • Drug Approval / organization & administration*
  • Drug Evaluation, Preclinical*
  • Flow Cytometry
  • Gene Expression Profiling
  • Humans
  • Mass Spectrometry
  • Mice
  • United States