Cognitive deficits and degeneration of interneurons in HIV+ methamphetamine users

Neurology. 2006 Oct 24;67(8):1486-9. doi: 10.1212/01.wnl.0000240066.02404.e6.


The cellular basis for cognitive deficits in HIV+ patients with and without a history of methamphetamine (METH) use is unclear. We found that HIV+ METH users had more severe loss of interneurons that was associated with cognitive impairment. Compared with other markers, loss of calbindin and parvalbumin interneurons in the frontal cortex was the most significant correlate to memory deficits, suggesting a role in neurobehavioral alterations of HIV+ METH users.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphetamine-Related Disorders / complications*
  • Cadaver
  • Cognition Disorders / etiology*
  • Cognition Disorders / psychology
  • Frontal Lobe / pathology
  • HIV Seropositivity / complications*
  • Humans
  • Interneurons / pathology*
  • Memory Disorders / etiology
  • Methamphetamine*
  • Nerve Degeneration / complications
  • Nerve Degeneration / etiology*
  • Nerve Degeneration / pathology*
  • Severity of Illness Index


  • Methamphetamine