Abstract
Bacillary dysentery (shigellosis) is a severe human disease caused by Shigellae. In recent years, a large amount of information has been generated regarding the host, pathogen and environmental factors that impact the pathogenesis of shigellosis at the cellular and molecular level. This review summarizes what is currently known about Shigella, detailing those factors that contribute to pathogenesis and examining the current progress in the development of a vaccine.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Carboxy-Lyases / genetics
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Carboxy-Lyases / physiology
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Dysentery, Bacillary / microbiology*
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Dysentery, Bacillary / physiopathology
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Dysentery, Bacillary / prevention & control
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Environment
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Epithelial Cells / microbiology
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Genes, Bacterial
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Genomic Islands / genetics
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Humans
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Iron / metabolism
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Plasmids / genetics
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Shiga Toxin / metabolism
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Shigella / genetics
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Shigella / immunology
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Shigella / pathogenicity
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Shigella / physiology*
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Shigella Vaccines
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Vacuoles / microbiology
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Virulence
Substances
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Shigella Vaccines
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Shiga Toxin
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Iron
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Carboxy-Lyases
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lysine decarboxylase