Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Proteomics approaches to the systems biology of cardiovascular diseases

J Lipid Res. 2007 Jan;48(1):1-8. doi: 10.1194/jlr.R600027-JLR200. Epub 2006 Oct 25.


Proteins play a central role in a systems view of biologic processes. This review provides an overview of proteomics from a systems perspective. We survey the key tools and methodologies used, present examples of how these are currently being used in the systems biology context, and discuss future directions.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Biomarkers / analysis
  • Cardiovascular Diseases / genetics*
  • Cardiovascular System
  • Humans
  • Proteome*
  • Proteomics / methods
  • Subcellular Fractions / ultrastructure
  • Systems Biology / methods
  • Systems Biology / trends


  • Biomarkers
  • Proteome