Characterization of reverse transcriptase activity and susceptibility to other nucleosides of AZT-resistant variants of HIV-1. Results from the Canadian AZT Multicentre Study

Ann N Y Acad Sci. 1990;616:346-55. doi: 10.1111/j.1749-6632.1990.tb17855.x.
No abstract available

Publication types

  • Clinical Trial
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / drug therapy*
  • Acquired Immunodeficiency Syndrome / epidemiology
  • Canada / epidemiology
  • Cells, Cultured
  • Drug Resistance, Microbial / genetics
  • Genetic Variation
  • HIV-1 / drug effects*
  • HIV-1 / enzymology
  • HIV-1 / genetics
  • HIV-1 / isolation & purification
  • Humans
  • Kinetics
  • Leukocytes, Mononuclear / drug effects
  • Leukocytes, Mononuclear / microbiology
  • Membrane Glycoproteins / metabolism
  • Nucleosides / pharmacology*
  • Nucleosides / therapeutic use
  • RNA-Directed DNA Polymerase / metabolism*
  • Sensitivity and Specificity
  • Viral Envelope Proteins / metabolism
  • Zidovudine / pharmacology*
  • Zidovudine / therapeutic use

Substances

  • Membrane Glycoproteins
  • Nucleosides
  • Viral Envelope Proteins
  • Zidovudine
  • RNA-Directed DNA Polymerase