Continuation of proton pump inhibitors from hospital to community

Pharm World Sci. 2006 Aug;28(4):189-93. doi: 10.1007/s11096-006-9028-4. Epub 2006 Oct 26.


Objectives: To evaluate the appropriateness of initiation of proton pump inhibitor (PPI) treatment in hospital, the quality of discharge information, and any association with continued treatment in the community.

Method: Survey of all inpatients newly initiated on a PPI in June-August 2003. Assessment of appropriateness of therapy and completeness of discharge information; assessment of continuation of PPI therapy in the community after 6 months.

Results: Thirty-five of 58 patients (60%) were considered appropriately commenced on PPI treatment. Less than 25% of patients discharged on a PPI had discharge information recommending duration of treatment or review. In the "appropriate" group 30 patients (86%) were discharged on omeprazole, and 13/21 (62%) evaluable patients remained on this at 6 months. In the "inappropriate" group 15 (65%) were discharged on omeprazole, and 10/14 (71%) evaluable patients remained on this at 6 months. Older patients remained on omeprazole for a longer duration but appropriateness of commencement did not influence the duration of treatment. Dose titration was attempted for 10 (29%) patients including three from the "inappropriate" group.

Conclusion: Care should be taken to commence PPIs only when clinically indicated. Discharge information to GPs, especially recommendations for duration of treatment and/or dose titration, requires improvement.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Anti-Ulcer Agents / pharmacology
  • Anti-Ulcer Agents / therapeutic use
  • Communication
  • Continuity of Patient Care / statistics & numerical data
  • Drug Evaluation / methods
  • Female
  • Follow-Up Studies
  • Hospitalization
  • Humans
  • Inpatients / statistics & numerical data*
  • Male
  • Middle Aged
  • Omeprazole / pharmacology
  • Omeprazole / therapeutic use*
  • Patient Discharge / standards
  • Patient Discharge / statistics & numerical data*
  • Proton Pump Inhibitors*
  • Risk Factors
  • Time Factors
  • Treatment Outcome


  • Anti-Ulcer Agents
  • Proton Pump Inhibitors
  • Omeprazole