Abstract
Four different types of marine natural compounds isolated from tunicates were found to inhibit human aldose reductase. They all are characterized by a heterocyclic system, and at least two phenolic groups are present in the structure. Two of the compounds tested showed an inhibitory potency 5/6-fold higher than that of the known AR inhibitor sorbinil. One notable structural feature of these active compounds is the lack of either the carboxylic acid or the spiro-hydantoin commonly present in the principal classes of currently used inhibitors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehyde Reductase / antagonists & inhibitors*
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Animals
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Biological Products / chemistry
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Biological Products / isolation & purification*
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Biological Products / pharmacology
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Humans
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Imidazolidines / chemistry
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Imidazolidines / isolation & purification*
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Imidazolidines / pharmacology
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Marine Biology
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Naphthalenes / chemistry
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Naphthalenes / isolation & purification*
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Naphthalenes / pharmacology
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Quinazolines / chemistry
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Quinazolines / isolation & purification*
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Quinazolines / pharmacology
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Rhodanine / analogs & derivatives*
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Rhodanine / chemistry
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Rhodanine / isolation & purification
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Rhodanine / pharmacology
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Thiazolidines / chemistry
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Thiazolidines / isolation & purification*
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Thiazolidines / pharmacology
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Urochordata / chemistry
Substances
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Biological Products
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Imidazolidines
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Naphthalenes
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Quinazolines
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Thiazolidines
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tolrestat
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FR 74366
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epalrestat
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Rhodanine
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AKR1B1 protein, human
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Aldehyde Reductase
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sorbinil