Cytotoxic cycloartane triterpene saponins from Actaea asiatica

J Nat Prod. 2006 Oct;69(10):1500-2. doi: 10.1021/np060113h.

Abstract

Three new 9,19-cycloartane triterpene glycosides, asiaticoside A (1), asiaticoside B (2), and 25-O-ethylcimigenol-3-O-beta-D-xylopyranoside (3), together with cimiacemoside I (4), 25-O-acetylcimigenol-3-beta-O-D-xyloside (5), and 25-anhydrocimigenol-beta-O-D-xyloside (6) were isolated from the roots/rhizomes extract of Actaea asiatica, and their structures were established by spectroscopic methods (IR, HRESIMS, and NMR). Compounds 1-3, 5, and 6 had notable cytotoxicity against HepG2 and MCF-7 cancer cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actaea / chemistry*
  • Animals
  • Antineoplastic Agents, Phytogenic* / chemistry
  • Antineoplastic Agents, Phytogenic* / isolation & purification
  • Antineoplastic Agents, Phytogenic* / pharmacology
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal* / chemistry
  • Drugs, Chinese Herbal* / isolation & purification
  • Drugs, Chinese Herbal* / pharmacology
  • Humans
  • Inhibitory Concentration 50
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Rhizome / chemistry
  • Saponins* / chemistry
  • Saponins* / isolation & purification
  • Saponins* / pharmacology
  • Triterpenes* / chemistry
  • Triterpenes* / isolation & purification
  • Triterpenes* / pharmacology

Substances

  • 25-O-ethylcimigenol-3-O-beta-D-xylopyranoside
  • Antineoplastic Agents, Phytogenic
  • Drugs, Chinese Herbal
  • Saponins
  • Triterpenes
  • asiaticoside B
  • cycloartane
  • madecassoside
  • asiaticoside