Toxoplasmic chorioretinitis and antitumor necrosis factor treatment in rheumatoid arthritis

Semin Arthritis Rheum. 2007 Feb;36(4):262-3. doi: 10.1016/j.semarthrit.2006.08.004. Epub 2006 Oct 25.

Abstract

Objectives: To present the data supporting the possible relationship of ocular toxoplasmosis to antitumor necrosis factor-alpha (TNF-alpha) therapy in patients with rheumatoid arthritis (RA).

Methods: A Medline search was performed using the words "toxoplasmosis, anti-TNF-alpha antagonists, chorioretinitis." We report 2 RA patients who developed ocular toxoplasmosis while receiving anti-TNF-alpha therapy.

Results: In addition to our patients with toxoplasmic chorioretinitis, there are 2 published cases of cerebral toxoplasmosis during treatment with anti-TNF-alpha agents.

Conclusion: The risk of serious toxoplasmic infection during anti-TNF-alpha therapy for RA should be recognized.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Animals
  • Antibodies, Monoclonal / adverse effects*
  • Antirheumatic Agents / adverse effects*
  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / parasitology
  • Chorioretinitis / parasitology
  • Female
  • Humans
  • Infliximab
  • Male
  • Toxoplasma
  • Toxoplasmosis, Ocular / chemically induced*
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors

Substances

  • Antibodies, Monoclonal
  • Antirheumatic Agents
  • Tumor Necrosis Factor-alpha
  • Infliximab