Household mouse allergen exposure and asthma morbidity in inner-city preschool children

Ann Allergy Asthma Immunol. 2006 Oct;97(4):514-20. doi: 10.1016/S1081-1206(10)60943-X.


Background: Inner-city children experience disproportionate asthma morbidity, and suspected reasons include indoor environmental exposures.

Objective: To determine if mouse allergen exposure is a risk factor for asthma morbidity.

Methods: Preschool children with asthma were recruited from inner-city Baltimore, MD. Skin testing was performed and blood was collected at the baseline visit for quantification of mouse allergen specific IgE. A questionnaire evaluated symptoms, medication, and health care use at baseline, 3 months, and 6 months. A trained technician collected dust samples from the child's home for analysis of Mus m 1 at baseline, 3 months, and 6 months. Outcomes were compared between mouse-sensitized, highly exposed children and all other children.

Results: A total of 127 children had complete data for mouse sensitization status and bedroom settled dust mouse allergen levels at baseline. The mean age of the children was 4.4 years, 92% were African American, and 26% were sensitized to mouse. Mouse-sensitized children exposed to higher levels of Mus m 1 (>0.5 microg/g) had 50% more days of symptoms (incidence rate ratio [IRR], 1.5; 95% confidence interval [CI], 1.1-2.1) and 80% more days of beta-agonist use than other children (IRR, 1.8; 95% CI, 1.3-2.5). Children in the sensitized and highly exposed group were also more likely to have an unscheduled physician visit (odds ratio [OR], 3.1; 95% CI, 1.6-6.3), emergency department visit (OR, 2.1; 95% CI, 1.1-4.1), and hospitalization (OR, 36.6; 95% CI, 4.1-327.3) than other children. These associations between mouse allergen exposure and asthma symptoms and morbidity remained statistically significant after adjusting for potential confounders, including atopy and cockroach sensitization and exposure.

Conclusions: In mouse-sensitized inner-city children, exposure to mouse allergen may be an important cause of asthma morbidity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Allergens / adverse effects
  • Allergens / immunology*
  • Animals
  • Asthma / epidemiology
  • Asthma / immunology*
  • Baltimore / epidemiology
  • Child
  • Child, Preschool
  • Environmental Exposure / adverse effects*
  • Environmental Exposure / analysis
  • Female
  • Humans
  • Male
  • Mice*
  • Poverty Areas
  • Public Housing
  • Urban Health*
  • Urban Population


  • Allergens