[Impact of CRP rapid test in management of febrile children in paediatric emergency units of Ile-de-France]

Arch Pediatr. 2006 Dec;13(12):1566-71. doi: 10.1016/j.arcped.2006.09.003. Epub 2006 Oct 27.
[Article in French]


Objective: Fever is a common cause of children visits to emergency units. Clinical evaluation does not always eliminate a bacterial infection. Among blood markers, several publications showed the interest of CRP. This study was undertaken to evaluate correlation between two techniques of CRP, one by usual technique at the laboratory and the other by a rapid test, and to evaluate the impact of this rapid test for febrile children at the emergency room, when a hospitalization was not immediately decided.

Material and methods: The study was undertaken in 2004-2005 in eight emergency paediatric units in Ile-de-France concerning febrile children during two periods. In period A, children had at the same time a CRP dosage through two methods, whereas in period B, only a rapid CRP test was first managed. The test used was NycoCard CRP Single test (Progen Biotechnique).

Results: Between September 2004 and June 2005, 572 children were included, 268 in period A and 304 in period B. Comparison of CRP results by the two methods showed for 247 children (93%) a fairly good linear correlation (r: 0.929). Blood cell count was the most often prescribed test (99.4 vs 10.5%). Conversely to chest radiography, blood culture, fibrinogen and urinary test were significantly most frequent in period A. The average cost of the additional examinations was 2.6 times more important during the first period. Duration of children management in the units was approximately two times shorter when rapid CRP test was used (199.7+/-92.8 vs 103.5+/-98.6 min).

Conclusion: This study shows the interest of rapid CRP test for febrile children in the emergency units, and has to be confirmed in ambulatory paediatric practice.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Adolescent
  • Age Factors
  • C-Reactive Protein / analysis*
  • Chi-Square Distribution
  • Child
  • Child, Preschool
  • Emergencies
  • Fever / blood*
  • Fever / diagnosis
  • Humans
  • Immunologic Tests
  • Infant
  • Infant, Newborn
  • Intensive Care Units, Pediatric
  • Length of Stay
  • Surveys and Questionnaires
  • Time Factors


  • C-Reactive Protein