Abstract
Since many nuclear proteins are ectopically localized in the cytoplasm in the vulnerable neurons in Alzheimer disease (AD), we speculated that there is failure of the cytoplasmic-nuclear transport machinery in AD. In support of this notion, we found that importin alpha1, an essential component of cytoplasmic-nuclear transport, is abnormally accumulated in Hirano bodies in vulnerable hippocampal neurons in AD. These data suggest a hindrance in importin-mediated cytoplasmic-nuclear transport in AD.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Actins / metabolism
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Aged
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Aged, 80 and over
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Alzheimer Disease / metabolism
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Alzheimer Disease / pathology*
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Case-Control Studies
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Hippocampus / pathology*
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Humans
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Immunohistochemistry / methods
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Neurofibrillary Tangles / metabolism
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Neurons / metabolism*
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Pick Disease of the Brain / metabolism
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Pick Disease of the Brain / pathology
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alpha Karyopherins / metabolism*
Substances
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Actins
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alpha Karyopherins
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karyopherin alpha 2