Health economics: a cost analysis of treatment of persistent fracture non-unions using bone morphogenetic protein-7

Injury. 2007 Mar;38(3):371-7. doi: 10.1016/j.injury.2006.08.055. Epub 2006 Oct 27.


Objective: To compare the cost implications of treatment of persistent fracture non-unions before and after application of recombinant human bone morphogenetic protein-7 (BMP-7).

Method: Of 25 fracture non-unions, 9 were treated using BMP-7 alone and 16 using BMP-7 and bone grafting. These patients were prospectively followed up, and the costs incurred were analysed.

Results: The mean number of procedures per fracture performed before application of BMP-7 was 4.16, versus 1.2 thereafter. Mean hospital stay and cost of treatment per fracture before receiving BMP-7 were 26.84 days and pound 13,844.68, versus 7.8 days and pound 7338.4 thereafter. The overall cost of treatment of persistent fracture non-unions with BMP-7 was 47.0% less than that of the numerous previous unsuccessful treatments (p=0.001).

Conclusions: Treating fracture non-unions is costly, but this could be reduced by early BMP-7 administration when a complex or persistent fracture non-union is present or anticipated.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Bone Morphogenetic Protein 7
  • Bone Morphogenetic Proteins / economics*
  • Bone Morphogenetic Proteins / therapeutic use*
  • Bone Regeneration
  • Bone Transplantation / economics*
  • Costs and Cost Analysis
  • Drug Costs
  • Female
  • Fracture Healing
  • Fractures, Bone / drug therapy*
  • Fractures, Bone / surgery
  • Fractures, Ununited / drug therapy*
  • Fractures, Ununited / surgery
  • Humans
  • Length of Stay / economics
  • Male
  • Middle Aged
  • Prospective Studies
  • Recombinant Proteins / economics
  • Recombinant Proteins / therapeutic use
  • Reoperation / economics
  • Transforming Growth Factor beta / economics*
  • Transforming Growth Factor beta / therapeutic use*
  • United Kingdom


  • BMP7 protein, human
  • Bone Morphogenetic Protein 7
  • Bone Morphogenetic Proteins
  • Recombinant Proteins
  • Transforming Growth Factor beta