Treating dopamimetic psychosis in Parkinson's disease: structured review and meta-analysis

Eur Neuropsychopharmacol. 2007 Feb;17(3):165-71. doi: 10.1016/j.euroneuro.2006.08.007. Epub 2006 Oct 27.


Psychosis due to dopamimetic treatment is a difficult problem in patients with Parkinson's disease (PD). The aim of this structured review with meta-analysis was to evaluate which neuroleptic drugs can efficiently be used to treat drug-induced psychosis (DIP) in Parkinson's disease. Electronic databases were screened for the key words Parkinson's disease and psychosis. Only 7 trials with a satisfactory allocation concealment and data reporting were included into the study. Two trials compared low-dose clozapine versus placebo with a significantly better outcome for clozapine regarding efficacy and motor functioning. In one trial clozapine was compared against quetiapine showing equivalent efficacy and tolerability. However, in two placebo controlled trials quetiapine failed to show efficacy. In two further placebo controlled trials olanzapine did not improve psychotic symptoms and significantly caused more extrapyramidal side effects. Based on randomized trial-derived evidence which is currently available, only clozapine can be fully recommended for the treatment of DIP in PD. Olanzapine should not be used in this indication.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Antipsychotic Agents / therapeutic use*
  • Benzodiazepines / therapeutic use
  • Clozapine / therapeutic use
  • Data Interpretation, Statistical
  • Dibenzothiazepines / therapeutic use
  • Dopamine / physiology*
  • Dopamine Agents / therapeutic use*
  • Humans
  • Olanzapine
  • Parkinson Disease / complications*
  • Parkinson Disease / drug therapy*
  • Psychotic Disorders / drug therapy*
  • Psychotic Disorders / etiology*
  • Quality Assurance, Health Care
  • Quetiapine Fumarate
  • Randomized Controlled Trials as Topic


  • Antipsychotic Agents
  • Dibenzothiazepines
  • Dopamine Agents
  • Benzodiazepines
  • Quetiapine Fumarate
  • Clozapine
  • Olanzapine
  • Dopamine