Determinants of quality of life in patients following pulmonary resection for lung cancer

Am J Surg. 2006 Nov;192(5):565-71. doi: 10.1016/j.amjsurg.2006.08.019.


Background: The purpose of the present study was to prospectively measure quality of life (QOL) before and after pulmonary resection for non-small cell lung cancer (NSCLC) and to determine which clinical perioperative variables predicted QOL.

Methods: Thirty-seven patients undergoing a curative resection for early-stage NSCLC were administered the Functional Assessment of Cancer Therapy-Lung (FACT-L) questionnaire serially. This was used to calculate a Trial Outcome Index (TOI), a measure of QOL.

Results: Perioperative variables associated with worse postoperative TOI included the presence of preoperative dyspnea (coefficient -7.89, 95% confidence interval -12.4 to -3.31, P = .01) and exposure to adjuvant chemotherapy (-14.7, -20.0 to -9.46, P = .001).

Conclusions: Preoperative dyspnea and postoperative chemotherapy are associated with worse postoperative QOL among patients with resected, early-stage NSCLC. As adjuvant and neoadjuvant therapy protocols become more prevalent for these patients, QOL issues may assume greater importance.

MeSH terms

  • Bronchoscopy
  • Carcinoma, Non-Small-Cell Lung / diagnosis
  • Carcinoma, Non-Small-Cell Lung / drug therapy
  • Carcinoma, Non-Small-Cell Lung / mortality
  • Carcinoma, Non-Small-Cell Lung / surgery*
  • Chemotherapy, Adjuvant
  • Comorbidity
  • Disease-Free Survival
  • Dyspnea / physiopathology
  • Female
  • Humans
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / mortality
  • Lung Neoplasms / physiopathology
  • Lung Neoplasms / surgery*
  • Male
  • Multivariate Analysis
  • Pneumonectomy*
  • Postoperative Period
  • Prospective Studies
  • Quality of Life*
  • Recovery of Function
  • Respiratory Function Tests
  • Risk Factors
  • Surveys and Questionnaires