Composite EBV negative peripheral T-cell lymphoma and diffuse large B-cell lymphoma involving the ileum: a case report and a systematic review of the literature

Leuk Lymphoma. 2006 Oct;47(10):2208-17. doi: 10.1080/10428190600763348.


We report a case of an intestinal peripheral T-cell lymphoma (PTCL) with a concurrent diffuse large B-cell lymphoma (DLBL) involving the ileum and a regional lymph node. The patient presented with an abdominal mass. The terminal ileum showed a diffuse and monotonous population of small CD3-positive T cells. The T-cell receptor gamma (TCRgamma) gene was rearranged by PCR while the immunoglobulin heavy chain (IgH) gene was not. A separate section of the ileum showed a colliding large B-cell proliferation. The regional lymph node showed a diffuse proliferation of large centroblasts positive for CD20 and CD79a admixed with small T cells and showed a rearranged IgH receptor gene without evidence of a clonally rearranged TCRgamma gene. Both the PTCL and DLBL components were negative for EBV. A review and analysis of the pertinent literature describing composite T- and B-cell lymphomas is performed and reported.

Publication types

  • Case Reports
  • Systematic Review

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • CD3 Complex / biosynthesis
  • Epstein-Barr Virus Infections* / complications
  • Female
  • Genes, T-Cell Receptor gamma
  • Herpesvirus 4, Human* / metabolism
  • Humans
  • Ileum* / pathology
  • Lymph Nodes / pathology
  • Lymphoma, B-Cell* / virology
  • Lymphoma, Large B-Cell, Diffuse* / virology
  • Lymphoma, T-Cell, Peripheral* / virology
  • Male
  • Middle Aged
  • Phenotype


  • CD3 Complex