NF-kappaB and the immune response

Oncogene. 2006 Oct 30;25(51):6758-80. doi: 10.1038/sj.onc.1209943.


One of the primary physiological roles of nuclear factor-kappa B (NF-kappaB) is in the immune system. In particular, NF-kappaB family members control the transcription of cytokines and antimicrobial effectors as well as genes that regulate cellular differentiation, survival and proliferation, thereby regulating various aspects of innate and adaptive immune responses. In addition, NF-kappaB also contributes to the development and survival of the cells and tissues that carry out immune responses in mammals. This review, therefore, describes the role of the NF-kappaB pathway in the development and functioning of the immune system.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adaptation, Physiological
  • Animals
  • Humans
  • Immune System / physiology*
  • Immunity, Innate
  • Lymphoid Tissue / growth & development
  • Lymphoid Tissue / immunology
  • NF-kappa B / physiology*


  • NF-kappa B