Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models

Oncogene. 2006 Oct 30;25(51):6781-99. doi: 10.1038/sj.onc.1209944.


The nuclear factor-kappaB (NF-kappaB) signalling pathway serves a crucial role in regulating the transcriptional responses of physiological processes that include cell division, cell survival, differentiation, immunity and inflammation. Here we outline studies using mouse models in which the core components of the NF-kappaB pathway, namely the IkappaB kinase subunits (IKKalpha, IKKbeta and NEMO), the IkappaB proteins (IkappaBalpha, IkappaBbeta, IkappaBvarepsilon and Bcl-3) and the five NF-kappaB transcription factors (NF-kappaB1, NF-kappaB2, c-Rel, RelA and RelB), have been genetically manipulated using transgenic and knockout technology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Female
  • Male
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Models, Animal*
  • NF-kappa B / metabolism*
  • Signal Transduction*


  • NF-kappa B