Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression

Oncogene. 2006 Oct 30;25(51):6817-30. doi: 10.1038/sj.onc.1209942.


Abundant data support a key role for the transcription factor nuclear factor-kappaB (NF-kappaB) signaling pathway in controlling the initiation and progression of human cancer. NF-kappaB and associated regulatory proteins such as IkappaB kinase (IKK) are activated downstream of many oncoproteins and there is much evidence for the activation of NF-kappaB-dependent target genes in a variety of solid tumors and hematologic malignancies. This review focuses on the mechanisms by which the NF-kappaB pathway is activated in cancer and on the oncogenic functions controlled by activated NF-kappaB. Additionally, the effects of NF-kappaB activation in tumors relative to cancer therapy are also discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic*
  • Genes, Tumor Suppressor
  • Humans
  • I-kappa B Kinase / antagonists & inhibitors*
  • NF-kappa B / antagonists & inhibitors
  • NF-kappa B / physiology*


  • NF-kappa B
  • I-kappa B Kinase