Cross-talk between nuclear receptors and nuclear factor kappaB

Oncogene. 2006 Oct 30;25(51):6868-86. doi: 10.1038/sj.onc.1209935.


A variety of studies have shown that some activated nuclear receptors (NRs), especially the glucorticoid receptor, the estrogen receptor and peroxisome proliferator-activated receptor, can inhibit the activity of the transcription factor nuclear factor kappaB (NF-kappaB), which plays a key role in the control of genes involved in inflammation, cell proliferation and apoptosis. This review describes the molecular mechanisms of cross-talk between NRs and NF-kappaB and the biological relevance of this cross-talk. The importance and mechanistic aspects of selective NR modulation are discussed. Also included are future research prospects, which will lead to a new era in the field of NR research with the aim of specifically inhibiting NF-kappaB-driven gene expression for anti-inflammatory, anti-tumor and immune-modulatory purposes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Hormones / metabolism*
  • Humans
  • NF-kappa B / metabolism*
  • Receptor Cross-Talk*
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Signal Transduction


  • Hormones
  • NF-kappa B
  • Receptors, Cytoplasmic and Nuclear