Regression analysis of failure time data with informative interval censoring

Stat Med. 2007 May 30;26(12):2533-46. doi: 10.1002/sim.2721.


Interval censoring arises when a subject misses prescheduled visits at which the failure is to be assessed. Most existing approaches for analysing interval-censored failure time data assume that the censoring mechanism is independent of the true failure time. However, there are situations where this assumption may not hold. In this paper, we consider such a situation in which the dependence structure between the censoring variables and the failure time can be modelled through some latent variables and a method for regression analysis of failure time data is proposed. The method makes use of the proportional hazards frailty model and an EM algorithm is presented for estimation. Finite sample properties of the proposed estimators of regression parameters are examined through simulation studies and we illustrate the method with data from an AIDS study.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acquired Immunodeficiency Syndrome / drug therapy
  • Acquired Immunodeficiency Syndrome / immunology
  • Algorithms*
  • Antiviral Agents / therapeutic use
  • Computer Simulation
  • Humans
  • Likelihood Functions
  • Pneumocystis Infections / blood
  • Pneumocystis Infections / drug therapy
  • Pneumocystis Infections / urine
  • Pneumocystis carinii / immunology
  • Proportional Hazards Models*
  • Regression Analysis*
  • Virus Shedding / drug effects


  • Antiviral Agents