Multidrug-resistant Mycobacterium tuberculosis, Bangui, Central African Republic

Laurent X Nouvel; Eric Kassa-Kelembho; Tiago Dos Vultos; Germain Zandanga; Jean Rauzier; Carmen Lafoz; Carlos Martin; Jesus Blazquez; Antoine Talarmin; Brigitte Gicquel

doi:10.3201/eid1209.060361

Multidrug-resistant Mycobacterium tuberculosis, Bangui, Central African Republic

Emerg Infect Dis. 2006 Sep;12(9):1454-6. doi: 10.3201/eid1209.060361.

Authors

Laurent X Nouvel¹, Eric Kassa-Kelembho, Tiago Dos Vultos, Germain Zandanga, Jean Rauzier, Carmen Lafoz, Carlos Martin, Jesus Blazquez, Antoine Talarmin, Brigitte Gicquel

Affiliation

¹ Institut Pasteur, Paris, France.

Abstract

We investigated multidrug-resistant (MDR) Mycobacterium tuberculosis strains in Bangui, Central African Republic. We found 39.6% with the same spoligotype and synonymous single nucleotide polymorphism in the mutT1 gene. However, strains had different rpoB mutations responsible for rifampin resistance. MDR strains in Bangui may emerge preferentially from a single, MDR-prone family.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antitubercular Agents / pharmacology
Bacterial Proteins / genetics
Central African Republic / epidemiology
DNA Repair
DNA-Directed RNA Polymerases
Humans
Mutation
Mycobacterium tuberculosis* / classification
Mycobacterium tuberculosis* / drug effects
Mycobacterium tuberculosis* / genetics
Mycobacterium tuberculosis* / isolation & purification
Oligonucleotides / analysis
Polymorphism, Single Nucleotide
Tuberculosis, Multidrug-Resistant / epidemiology*
Tuberculosis, Multidrug-Resistant / microbiology*

Substances

Antitubercular Agents
Bacterial Proteins
Oligonucleotides
rpoB protein, Mycobacterium tuberculosis
DNA-Directed RNA Polymerases