Neutrophil infiltration and chemokines

Crit Rev Immunol. 2006;26(4):307-16. doi: 10.1615/critrevimmunol.v26.i4.20.


Neutrophil infiltration is mainly mediated by ELR+ CXC chemokines and is regulated through interactions between various stimulants and cells, which are perhaps more complex than previously thought. In this review, I describe the current view of the roles of neutrophil-selective chemokines such as IL-8, MIP-2, and KC by choosing several in vivo models. I also illustrate how these three chemokines are induced and how they are involved in neutrophil infiltration. Finally, I introduce synthetic compounds with high efficacy in the prevention of ischemia reperfusion injury.

Publication types

  • Review

MeSH terms

  • Animals
  • Chemokines / antagonists & inhibitors
  • Chemokines / genetics
  • Chemokines / physiology*
  • Humans
  • Inflammation / immunology
  • Neutrophil Infiltration*
  • Neutrophils / immunology*
  • Reperfusion Injury / immunology
  • Reperfusion Injury / prevention & control


  • Chemokines