Human beta-defensin-3: a promising antimicrobial peptide

Mini Rev Med Chem. 2006 Oct;6(10):1063-73. doi: 10.2174/138955706778560193.


The field of naturally occurring antimicrobial peptides is a research area rapidly expanding due to the high potential of such molecules as new antimicrobial drugs. In this regard, the human beta-defensin-3 is particularly attractive because of its strong antibacterial activity, relative salt-insensitiveness and low toxicity for host cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Bacteria / drug effects*
  • Fungi / drug effects*
  • Gene Expression Regulation
  • Humans
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Protein Structure, Secondary
  • RNA, Messenger / genetics
  • beta-Defensins / chemistry*
  • beta-Defensins / genetics
  • beta-Defensins / pharmacology*


  • DEFB103A protein, human
  • RNA, Messenger
  • beta-Defensins