The chemoattractant decoy receptor D6 as a negative regulator of inflammatory responses

Biochem Soc Trans. 2006 Dec;34(Pt 6):1014-7. doi: 10.1042/BST0341014.

Abstract

Other than signalling receptors sustaining leucocyte recruitment during inflammatory reactions, the chemokine system includes 'silent' receptors with distinct specificity and tissue distribution. The best-characterized molecule of this subgroup is the CC chemokine receptor D6, which binds most inflammatory CC chemokines and targets them to degradation via constitutive ligand-independent internalization. Structure-function analysis and recent results with gene-targeted animals indicate that D6 has unique functional and structural features, which make it ideally adapted to act as a chemokine decoy and scavenger receptor, strategically located on lymphatic endothelium and placenta to dampen inflammation in tissues and draining lymph nodes.

MeSH terms

  • Humans
  • Inflammation / physiopathology*
  • Leukocytes / physiology*
  • Ligands
  • Lymphatic Vessels / physiology
  • Models, Biological
  • Receptors, CCR10
  • Receptors, Chemokine / physiology*
  • Receptors, Interleukin-1 / physiology

Substances

  • Ligands
  • Receptors, CCR10
  • Receptors, Chemokine
  • Receptors, Interleukin-1
  • chemokine receptor D6