Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Oct;47(10):987-93.
doi: 10.1111/j.1469-7610.2006.01676.x.

A Pediatric Twin Study of Brain Morphometry


A Pediatric Twin Study of Brain Morphometry

Gregory L Wallace et al. J Child Psychol Psychiatry. .


Background: Longitudinal pediatric neuroimaging studies have demonstrated increasing volumes of white matter and regionally-specific inverted U shaped developmental trajectories of gray matter volumes during childhood and adolescence. Studies of monozygotic and dyzygotic twins during this developmental period allow exploration of genetic and non-genetic influences on these developmental trajectories.

Method: Magnetic resonance imaging brain scans were acquired on a pediatric sample of 90 monozygotic twin pairs, 38 same-sex dyzygotic twin pairs, and 158 unrelated typically developing singletons. Structural equation modeling was used to estimate the additive genetic, common environment, and unique environment effects, as well as age by heritability interactions, on measures of brain volumes from these images.

Results: Consistent with previous adult studies, additive genetic effects accounted for a substantial portion of variability in nearly all brain regions with the notable exception of the cerebellum. Significant age by heritability interactions were observed with gray matter volumes showing a reduction in heritability with increasing age, while white matter volume heritability increased with greater age.

Conclusion: Understanding the relative contributions of genetic and nongenetic factors on developmental brain trajectories may have implications for better understanding brain-based disorders and typical cognitive development.

Similar articles

See all similar articles

Cited by 72 articles

  • Disturbed Cerebellar Growth Trajectories in Adolescents Who Initiate Alcohol Drinking.
    Sullivan EV, Brumback T, Tapert SF, Brown SA, Baker FC, Colrain IM, Prouty D, De Bellis MD, Clark DB, Nagel BJ, Pohl KM, Pfefferbaum A. Sullivan EV, et al. Biol Psychiatry. 2020 Apr 1;87(7):632-644. doi: 10.1016/j.biopsych.2019.08.026. Epub 2019 Sep 9. Biol Psychiatry. 2020. PMID: 31653477
  • A genome-wide association study identifies genetic loci associated with specific lobar brain volumes.
    van der Lee SJ, Knol MJ, Chauhan G, Satizabal CL, Smith AV, Hofer E, Bis JC, Hibar DP, Hilal S, van den Akker EB, Arfanakis K, Bernard M, Yanek LR, Amin N, Crivello F, Cheung JW, Harris TB, Saba Y, Lopez OL, Li S, van der Grond J, Yu L, Paus T, Roshchupkin GV, Amouyel P, Jahanshad N, Taylor KD, Yang Q, Mathias RA, Boehringer S, Mazoyer B, Rice K, Cheng CY, Maillard P, van Heemst D, Wong TY, Niessen WJ, Beiser AS, Beekman M, Zhao W, Nyquist PA, Chen C, Launer LJ, Psaty BM, Ikram MK, Vernooij MW, Schmidt H, Pausova Z, Becker DM, De Jager PL, Thompson PM, van Duijn CM, Bennett DA, Slagboom PE, Schmidt R, Longstreth WT, Ikram MA, Seshadri S, Debette S, Gudnason V, Adams HHH, DeCarli C. van der Lee SJ, et al. Commun Biol. 2019 Aug 2;2:285. doi: 10.1038/s42003-019-0537-9. eCollection 2019. Commun Biol. 2019. PMID: 31396565 Free PMC article.
  • A Comprehensive Quantitative Genetic Analysis of Cerebral Surface Area in Youth.
    Schmitt JE, Neale MC, Clasen LS, Liu S, Seidlitz J, Pritikin JN, Chu A, Wallace GL, Lee NR, Giedd JN, Raznahan A. Schmitt JE, et al. J Neurosci. 2019 Apr 17;39(16):3028-3040. doi: 10.1523/JNEUROSCI.2248-18.2019. Epub 2019 Mar 4. J Neurosci. 2019. PMID: 30833512 Free PMC article.
  • The Dynamic Associations Between Cortical Thickness and General Intelligence are Genetically Mediated.
    Schmitt JE, Raznahan A, Clasen LS, Wallace GL, Pritikin JN, Lee NR, Giedd JN, Neale MC. Schmitt JE, et al. Cereb Cortex. 2019 Dec 17;29(11):4743-4752. doi: 10.1093/cercor/bhz007. Cereb Cortex. 2019. PMID: 30715232
  • Genetic and environmental influences on structural brain measures in twins with autism spectrum disorder.
    Hegarty JP 2nd, Pegoraro LFL, Lazzeroni LC, Raman MM, Hallmayer JF, Monterrey JC, Cleveland SC, Wolke ON, Phillips JM, Reiss AL, Hardan AY. Hegarty JP 2nd, et al. Mol Psychiatry. 2019 Jan 18:10.1038/s41380-018-0330-z. doi: 10.1038/s41380-018-0330-z. Online ahead of print. Mol Psychiatry. 2019. PMID: 30659287 Free PMC article.
See all "Cited by" articles

Publication types

LinkOut - more resources