DTNBP1 genotype influences cognitive decline in schizophrenia

Schizophr Res. 2007 Jan;89(1-3):169-72. doi: 10.1016/j.schres.2006.09.008. Epub 2006 Oct 30.


Objective: Intellectual decline is common in schizophrenia and predicts functional outcome. While many patients undergo intellectual decline that typically predates the onset of symptoms, few studies have investigated the underlying mechanism through which this occurs. The current study assessed the relationship between intellectual decline in schizophrenia and genetic variation in dysbindin-1 (DTNBP1).

Methods: We assessed cognitive decline in 183 Caucasian patients with schizophrenia using a proxy measure of premorbid IQ with which current general cognitive ability (g) was compared. We then tested for a relationship between the risk haplotype identified in previous work (CTCTAC) and intellectual decline.

Results: We found that carriers of the CTCTAC haplotype, demonstrated a significantly greater decline in IQ as compared with non-carriers (p=0.05).

Conclusions: These data suggest that DTNBP1 influences the severity of intellectual decline in schizophrenia and may represent one underlying cause for heterogeneity in cognitive course.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Carrier Proteins / genetics*
  • Cognition Disorders / diagnosis
  • Cognition Disorders / genetics*
  • Cognition Disorders / psychology
  • Disease Progression
  • Dysbindin
  • Dystrophin-Associated Proteins
  • Female
  • Genetic Carrier Screening
  • Genetic Predisposition to Disease / genetics
  • Genotype*
  • Haplotypes
  • Humans
  • Intelligence / genetics
  • Male
  • Middle Aged
  • Psychotic Disorders / diagnosis
  • Psychotic Disorders / genetics*
  • Psychotic Disorders / psychology
  • Risk Factors
  • Schizophrenia / diagnosis
  • Schizophrenia / genetics*
  • Schizophrenic Psychology*
  • Wechsler Scales


  • Carrier Proteins
  • DTNBP1 protein, human
  • Dysbindin
  • Dystrophin-Associated Proteins