Leaner and meaner genomes in Escherichia coli

Genome Biol. 2006;7(10):237. doi: 10.1186/gb-2006-7-10-237. Epub 2006 Oct 24.


A 'better' Escherichia coli K-12 genome has recently been engineered in which about 15% of the genome has been removed by planned deletions. Comparison with related bacterial genomes that have undergone a natural reduction in size suggests that there is plenty of scope for yet more deletions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Mapping
  • Escherichia coli K12 / genetics*
  • Escherichia coli Proteins / genetics
  • Genome, Bacterial*
  • Models, Genetic


  • Escherichia coli Proteins