Efficacy of topical cyclosporine 0.05% in the treatment of dry eye associated with graft versus host disease

Cornea. 2006 Jul;25(6):674-8. doi: 10.1097/01.ico.0000208813.17367.0c.


Purpose: To assess the efficacy of topical cyclosporine 0.05% (Restasis) in patients with dry eye associated with graft versus host disease after stem cell transplantation.

Methods: After completing a 3-month run-in period of using only artificial tears to control dry eye symptoms in both eyes, patients who failed to achieve adequate relief (n = 8) were instructed to instill topical cyclosporine twice a day. Visual acuity, slit-lamp appearance, and intraocular pressure were evaluated every 2 weeks for a minimum of 3 months. In addition, Schirmer basal secretion tests, noninvasive fluorescein breakup time, and tear lysozyme were also performed. Patients were also given a dry eye questionnaire regarding symptoms of burning, tearing, and blurred vision.

Results: Dry eye signs improved significantly with cyclosporine treatment in 7 of 8 patients. Cyclosporine provided statistically significant improvements in Schirmer basal secretion scores (P = 0.003), tear breakup time (P = 0.002), and tear lysozyme levels (P = 0.033) after 3 months of treatment.

Conclusion: The findings in this prospective study suggest that dry eye associated with graft versus host disease can be effectively treated with topical cyclosporine, especially in patients unresponsive to other treatment modalities. These findings should be further evaluated in large-scale, controlled clinical trials.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Adult
  • Cyclosporine / administration & dosage*
  • Dry Eye Syndromes / drug therapy*
  • Dry Eye Syndromes / etiology
  • Female
  • Graft vs Host Disease / complications
  • Graft vs Host Disease / drug therapy*
  • Humans
  • Immunosuppressive Agents / administration & dosage*
  • Male
  • Middle Aged
  • Muramidase / metabolism
  • Prospective Studies
  • Surveys and Questionnaires
  • Tears / metabolism
  • Treatment Outcome
  • Visual Acuity


  • Immunosuppressive Agents
  • Cyclosporine
  • Muramidase