Children may experience pain when treated in almost every field of medicine; in the Emergency department, the admission ward, or in the ambulatory clinic. Pain assessment and treatment should be an integral part of the practice of pediatrics; all of us should adopt the advocacy role to ensure humane and competent treatment of pain and suffering in children. Failure to provide adequate treatment for pain can be equated to substandard and unethical medical practice. This editorial emphasizes the progress that has been made in the research of pediatric pain and its projection on the clinical field.