Roles of phosphatidate phosphatase enzymes in lipid metabolism

Trends Biochem Sci. 2006 Dec;31(12):694-9. doi: 10.1016/j.tibs.2006.10.003. Epub 2006 Oct 31.


Phosphatidate phosphatase (PAP) enzymes catalyze the dephosphorylation of phosphatidate, yielding diacylglycerol and inorganic phosphate. In eukaryotic cells, PAP activity has a central role in the synthesis of phospholipids and triacylglycerol through its product diacylglycerol, and it also generates and/or degrades lipid-signaling molecules that are related to phosphatidate. There are two types of PAP enzyme, Mg(2+) dependent (PAP1) and Mg(2+) independent (PAP2), but only genes encoding PAP2 enzymes had been identified until recently, when a gene (PAH1) encoding a PAP1 enzyme was found in Saccharomyces cerevisiae. This discovery has revealed a molecular function of the mammalian protein lipin, a deficiency of which causes lipodystrophy in mice. With molecular information now available for both types of PAP, the specific roles of these enzymes in lipid metabolism are being clarified.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Catalytic Domain
  • Gene Expression Regulation
  • Humans
  • Lipid Metabolism*
  • Lipids / chemistry
  • Lipodystrophy / pathology
  • Magnesium / chemistry
  • Mice
  • Models, Biological
  • Mutation
  • Pancreatitis-Associated Proteins
  • Phosphatidate Phosphatase / physiology*
  • Phospholipids / chemistry
  • Saccharomyces cerevisiae / metabolism
  • Signal Transduction


  • Lipids
  • Pancreatitis-Associated Proteins
  • Phospholipids
  • REG3A protein, human
  • Phosphatidate Phosphatase
  • Magnesium