Quality of life and depressive symptoms in patients with major depression and end-stage renal disease: a matched-pair study

J Psychosom Res. 2006 Nov;61(5):731-4. doi: 10.1016/j.jpsychores.2006.04.011.


Objective: To compare the quality of life (QOL) and depressive symptoms of outpatients with major depression with that of nondepressed individuals undergoing hemodialysis (matched for age, gender, and ethnicity).

Methods: We used the WHOQOL BREF and the Beck Depression Inventory (BDI).

Results: After univariate analyses, depressed patients' QOL scores were significantly lower (P<.0001) in all the assessed domains (i.e., physical health, psychological, social relationships, environmental, and global QOL). Additionally, there was a significant difference in the severity of depression among the study groups (P<.0001). Finally, after multiple regression analysis, the QOL profile of depressed subjects remained significantly worse even when controlling for depression scores and diagnostic status.

Conclusion: The subjective QOL of patients with major depression is significantly lower than that of subjects undergoing hemodialysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Comorbidity
  • Depressive Disorder, Major / diagnosis
  • Depressive Disorder, Major / psychology*
  • Female
  • Humans
  • Kidney Failure, Chronic / psychology*
  • Male
  • Matched-Pair Analysis
  • Middle Aged
  • Personality Inventory
  • Quality of Life / psychology*
  • Renal Dialysis / psychology
  • Sick Role
  • Statistics as Topic