Dissecting mitochondrial fusion

Dev Cell. 2006 Nov;11(5):592-4. doi: 10.1016/j.devcel.2006.10.009.

Abstract

Because mitochondria have outer and inner membranes, the fusion of two mitochondria requires the coordinated fusion of four lipid bilayers. Fusion of the outer membranes requires mitofusins. A new study published in Cell (Meeusen et al., 2006) shows that inner membrane fusion requires the dynamin-related protein Mgm1/OPA1.

MeSH terms

  • Dynamins / metabolism
  • GTP Phosphohydrolases / metabolism*
  • GTP-Binding Proteins / metabolism
  • Membrane Fusion*
  • Membrane Proteins / metabolism
  • Mitochondria / physiology*
  • Mitochondria / ultrastructure
  • Mitochondrial Membranes / physiology*
  • Mitochondrial Proteins / metabolism
  • Models, Biological
  • Saccharomyces cerevisiae Proteins / metabolism

Substances

  • MGM1 protein, S cerevisiae
  • Membrane Proteins
  • Mitochondrial Proteins
  • Saccharomyces cerevisiae Proteins
  • UGO1 protein, S cerevisiae
  • FZO1 protein, S cerevisiae
  • GTP Phosphohydrolases
  • GTP-Binding Proteins
  • Dynamins