SUMO: the glue that binds

Dev Cell. 2006 Nov;11(5):596-7. doi: 10.1016/j.devcel.2006.10.011.


Two articles in a recent issue of Molecular Cell (Shen et al., 2006; Lin et al., 2006) demonstrate that noncovalent interactions between the SUMO moieties of SUMO-modified PML, and SUMO binding motifs on PML and other PML nuclear-body-associated proteins, affect the assembly of PML nuclear bodies and the recruitment of proteins in and out of these subnuclear structures.

MeSH terms

  • Amino Acid Motifs
  • Animals
  • Cell Nucleus / metabolism*
  • Cell Nucleus Structures / metabolism
  • Humans
  • Nuclear Proteins / metabolism*
  • Protein Binding
  • Protein Structure, Tertiary
  • Small Ubiquitin-Related Modifier Proteins / metabolism*


  • Nuclear Proteins
  • Small Ubiquitin-Related Modifier Proteins