DNA-damage control: Claspin destruction turns off the checkpoint

Benjamin E Gewurz; J Wade Harper

doi:10.1016/j.cub.2006.09.046

DNA-damage control: Claspin destruction turns off the checkpoint

Curr Biol. 2006 Nov 7;16(21):R932-4. doi: 10.1016/j.cub.2006.09.046.

Authors

Benjamin E Gewurz¹, J Wade Harper

Affiliation

¹ Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.

PMID: 17084694
DOI: 10.1016/j.cub.2006.09.046

Abstract

The ATR-Claspin-Chk1 pathway is critical for turning on the cellular response to DNA damage and replication stress. Five recent reports uncover new mechanisms controlling the recovery phase of the checkpoint response, and introduce crucial roles for Claspin, Rad17 phosphorylation and the ubiquitin proteasome pathway in Chk1 signaling.

MeSH terms

Adaptor Proteins, Signal Transducing
Animals
Cell Cycle
Cell Cycle Proteins / metabolism
Cell Line
Checkpoint Kinase 1
DNA Damage*
DNA Repair / physiology*
Phosphorylation
Proteasome Endopeptidase Complex / metabolism
Protein Kinases / metabolism
Protein Serine-Threonine Kinases / metabolism
Signal Transduction*
Ubiquitin / metabolism

Substances

Adaptor Proteins, Signal Transducing
Cell Cycle Proteins
Ubiquitin
Protein Kinases
Checkpoint Kinase 1
Protein Serine-Threonine Kinases
Proteasome Endopeptidase Complex