Hydrolyzed protein diets for dogs and cats

Vet Clin North Am Small Anim Pract. 2006 Nov;36(6):1251-68, vi. doi: 10.1016/j.cvsm.2006.08.008.


The primary aim of a hydrolyzed protein diet is to disrupt the proteins within the diet sufficiently to remove existing allergens. Published assessment of hydrolyzed protein diets includes physiochemical and immunologic assays as well as nutritional and clinical feeding trials. Potential problems include poor palatability, hypoosmotic diarrhea, and a reduced nutritional value, although persistent allergenicity is the most significant. The primary indications for a hydrolyzed protein diet are use in elimination trials for the diagnosis of adverse food reactions, and the initial management of inflammatory bowel disease. Initial studies of hydrolyzed diet efficacy are encouraging. Consideration of the source ingredients should be given when using hydrolyzed protein diets in elimination feeding trials because antigenic sites may not be fully destroyed.

Publication types

  • Review

MeSH terms

  • Animal Nutritional Physiological Phenomena*
  • Animals
  • Cat Diseases / diet therapy*
  • Cats
  • Diet
  • Dietary Proteins / administration & dosage*
  • Dietary Proteins / adverse effects
  • Dietary Proteins / immunology
  • Dog Diseases / diet therapy*
  • Dogs
  • Food Hypersensitivity / diet therapy
  • Food Hypersensitivity / veterinary*
  • Hydrolysis
  • Inflammatory Bowel Diseases / diet therapy
  • Inflammatory Bowel Diseases / veterinary


  • Dietary Proteins