ERK1/2 MAP kinases in cell survival and apoptosis

IUBMB Life. 2006 Nov;58(11):621-31. doi: 10.1080/15216540600957438.

Abstract

ERK1/2 is an important subfamily of mitogen-activated protein kinases that control a broad range of cellular activities and physiological processes. ERK1/2 can be activated transiently or persistently by MEK1/2 and upstream MAP3Ks in conjunction with regulation and involvement of scaffolding proteins and phosphatases. Activation of ERK1/2 generally promotes cell survival; but under certain conditions, ERK1/2 can have pro-apoptotic functions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Apoptosis / physiology*
  • Cell Survival / physiology
  • Extracellular Signal-Regulated MAP Kinases / physiology*
  • Humans
  • MAP Kinase Kinase 1 / physiology
  • MAP Kinase Kinase 2 / physiology
  • MAP Kinase Kinase Kinases / physiology
  • MAP Kinase Signaling System / physiology*
  • Mitogen-Activated Protein Kinase 1 / physiology
  • Mitogen-Activated Protein Kinase 3 / physiology

Substances

  • Extracellular Signal-Regulated MAP Kinases
  • Mitogen-Activated Protein Kinase 1
  • Mitogen-Activated Protein Kinase 3
  • MAP Kinase Kinase Kinases
  • MAP Kinase Kinase 1
  • MAP Kinase Kinase 2