Safety and efficacy of echinacea (Echinacea angustafolia, e. purpurea and e. pallida) during pregnancy and lactation

Can J Clin Pharmacol. Fall 2006;13(3):e262-7. Epub 2006 Nov 3.

Abstract

Background: There is a lack of basic knowledge on the part of both clinicians and patients as to the indications for use and safety of herbal medicines used in pregnancy and lactation. This is one article in a series that systematically reviews the evidence for commonly used herbs during pregnancy and lactation.

Objectives: To systematically review the literature for evidence on the use, safety, and pharmacology of echinacea focusing on issues pertaining to pregnancy and lactation.

Methods: We searched 7 electronic databases and compiled data according to the grade of evidence found.

Results: There is good scientific evidence from a prospective cohort study that oral consumption of echinacea during the first trimester does not increase the risk for major malformations. Low-level evidence based on expert opinion shows that oral consumption of echinacea in recommended doses is safe for use during pregnancy and lactation.

Conclusions: Echinacea is non-teratogenic when used during pregnancy. Caution with using Echinacea during lactation until further high quality human studies can determine its safety.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Animals
  • Echinacea* / adverse effects
  • Female
  • Herb-Drug Interactions
  • Humans
  • Lactation*
  • Lethal Dose 50
  • Plant Leaves
  • Plant Preparations* / administration & dosage
  • Plant Preparations* / adverse effects
  • Plant Preparations* / chemistry
  • Plant Preparations* / pharmacology
  • Plant Preparations* / therapeutic use
  • Plant Preparations* / toxicity
  • Plant Roots
  • Plant Stems
  • Pregnancy*
  • Risk Assessment

Substances

  • Plant Preparations