CoREST-like complexes regulate chromatin modification and neuronal gene expression

J Mol Neurosci. 2006;29(3):227-39. doi: 10.1385/JMN:29:3:227.

Abstract

The mammalian CoREST ([co]repressor for element-1-silencing transcription factor) complex was first identified associated with the repressor for element-1 silencing transcription factor (REST)/neuronal restrictive silencing factor. The CoREST complex is a chromatin-modifying corepressor complex that acts with REST to regulate neuronal gene expression and neuronal stem cell fate. Components of a CoREST-like complex have been identified recently in Xenopus laevis, Caenorhabditis elegans, and Drosophila melanogaster. Like the mammalian complex, the Drosophila complex is required to regulate neuronal gene expression, whereas the C. elegans homologs regulate the expression of the hop-1 presenilin gene, suggesting an ancient conserved function of CoREST complexes in regulating neuronal gene expression.

Publication types

  • Review

MeSH terms

  • Animals
  • Arabidopsis Proteins / physiology
  • Biological Evolution
  • Caenorhabditis elegans Proteins / physiology
  • Cell Cycle Proteins
  • Chromatin / genetics
  • Chromatin / metabolism*
  • Co-Repressor Proteins
  • DNA-Binding Proteins / physiology
  • Drosophila Proteins / physiology
  • Epigenesis, Genetic
  • Gene Expression Regulation*
  • High Mobility Group Proteins / physiology
  • Histone Deacetylase 1
  • Histone Deacetylase 2
  • Histone Deacetylases / physiology
  • Histone Demethylases
  • Humans
  • Invertebrates / genetics
  • Invertebrates / metabolism
  • Mammals / genetics
  • Mammals / metabolism
  • Mice
  • Multiprotein Complexes / physiology*
  • Nerve Tissue Proteins / biosynthesis
  • Nerve Tissue Proteins / genetics*
  • Nerve Tissue Proteins / physiology
  • Neurons / metabolism*
  • Oxidoreductases, N-Demethylating / physiology
  • Promoter Regions, Genetic
  • Proto-Oncogene Proteins c-raf / physiology
  • Repressor Proteins / physiology*
  • Transcription Factors / physiology*
  • Transcription, Genetic / physiology

Substances

  • Arabidopsis Proteins
  • Caenorhabditis elegans Proteins
  • Cell Cycle Proteins
  • Chromatin
  • Co-Repressor Proteins
  • DNA-Binding Proteins
  • Drosophila Proteins
  • HMG20B protein, human
  • High Mobility Group Proteins
  • Hmg20b protein, mouse
  • Multiprotein Complexes
  • Nerve Tissue Proteins
  • Phf21a protein, mouse
  • RCOR1 protein, human
  • RE1-silencing transcription factor
  • Repressor Proteins
  • Transcription Factors
  • Histone Demethylases
  • KDM1a protein, mouse
  • KDM1A protein, human
  • Oxidoreductases, N-Demethylating
  • SPR-5 protein, C elegans
  • Proto-Oncogene Proteins c-raf
  • PHF21A protein, human
  • HDAC1 protein, human
  • Hdac1 protein, mouse
  • Hdac2 protein, mouse
  • Histone Deacetylase 1
  • Histone Deacetylase 2
  • Histone Deacetylases