[A search for amyloidogenic regions in protein chain]

Mol Biol (Mosk). 2006 Sep-Oct;40(5):910-8.
[Article in Russian]


We suggest a new method to detect amyloidogenic regions in a protein sequence. In the present work it is shown that regions enriched with amino acid residues which have a high expected packing density are responsible for the amyloid formation. Our predictions are consistent with known disease-related amyloidogenic regions for 8 of 11 amyloid-forming proteins and peptides in which positions of amyloidogenic regions have been revealed experimentally.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid / chemistry*
  • Databases, Protein
  • Models, Chemical*
  • Protein Folding
  • Protein Structure, Tertiary
  • Proteins / chemistry*


  • Amyloid
  • Proteins