Effects of fenugreek seeds (Trigonella foenum greaecum) extract on endurance capacity in mice

J Nutr Sci Vitaminol (Tokyo). 2006 Aug;52(4):287-92. doi: 10.3177/jnsv.52.287.


The present study was designed to determine the effect of fenugreek seed extract (FG) on endurance capacity in male mice aged 4 wk. Mice were given orally either vehicle or FG (150, 300 mg/kg body weight) by stomach intubation for 4 wk. The 300 mg/ kg FG group showed a significant increase in swimming time to exhaustion as compared to the control group. In the FG groups, blood lactate concentration was significantly lower than in the control group. In the control group, plasma non-esterified fatty acid (NEFA) and plasma glucose were decreased by swimming exercise. But in the FG group, NEFA and plasma glucose were significantly increased by swimming. FG treatment also significantly decreased fat accumulation. These results suggest that improvement in swimming endurance by the administration of FG is caused by the increase in utilization of fatty acids as an energy source.

MeSH terms

  • Adipose Tissue / anatomy & histology
  • Animals
  • Blood Glucose / analysis
  • Fatty Acids, Nonesterified / blood
  • Glycogen / analysis
  • Kinetics
  • Lactic Acid / blood
  • Liver / chemistry
  • Liver / drug effects
  • Male
  • Mice
  • Muscle, Skeletal / chemistry
  • Muscle, Skeletal / drug effects
  • Organ Size / drug effects
  • Physical Endurance / drug effects*
  • Plant Extracts / administration & dosage*
  • Seeds / chemistry*
  • Swimming
  • Trigonella / chemistry*


  • Blood Glucose
  • Fatty Acids, Nonesterified
  • Plant Extracts
  • Lactic Acid
  • Glycogen